Insertional mutagenesis is mutagenesis of DNA by the insertion of one or more bases. Insertional mutations can occur naturally, mediated by virus or transposon, or can be artificially created for research purposes in the lab. == Signature tagged mutagenesis == This is a technique used to study the function of genes. A transposon, such as the Droso...
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(from the article `cancer`) ...by inserting their genomes into critical sites in the cellular genome—next to or within a proto-oncogene, for example—which thereby converts it ...
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http://www.britannica.com/eb/a-z/i/25
Generally, mutagenesis of DNA by the insertion of one or more bases. Specific examples: ... 1. Oncogenesis by insertion of a retrovirus adjacent to a cellular proto-oncogene. ... 2. A strategy of mutagenesis with transposons. After a round of transposition, progeny are screened by PCR, with transposon and gene specific primers, for the proximity of...
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http://www.encyclo.co.uk/local/20973
Generally, mutagenesis of DNA by the insertion of one or more bases. Specific examples: (1) oncogenesis by insertion of a retrovirus adjacent to a cellular proto-oncogene; (2) a strategy of mutagenesis with transposons. After a round of transposition, progeny are screened by PCR, with transposon- and gene-specific primers, for the proximity of the transposon sequence to the gene of interest. As PCR can only produce products up to 1-2 kb, a large fraction of progeny identified as positive by PCR will have a transposon close enough to the gene to inactivate or otherwise alter its pattern of expression.
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Type: Term Definitions: 1. mutation caused by insertion of new genetic material into a normal gene, particularly of retroviruses into chromosomal DNA.
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http://www.medilexicon.com/medicaldictionary.php?t=58033
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